| Caractère | Acteur |
|---|---|
| Jake Sully | Sam Worthington |
| Neytiri | Zoé Saldana |
| Colonel Miles Quaritch | Stephen Lang |
| Dr Grace Augustine | Sigourney Tisserand |
| Trudy Chacón | Michelle Rodriguez |
| Tsu'tey | Laz Alonso |
| Parker Selfridge | Giovanni Ribisi |
| Norme Spellman | Joël David Moore |
| Dr Max Patel | Dileep Rao |
| Eytukan | Wes Studi |
| Mo'at | Pilon CCH |